U.S. Route 60 or U.S. Highway 60 (US 60) is an east–west major United States highway, traveling 2,670 miles (4,300 km) from southwestern Arizona to the Atlantic coast in Virginia. Despite the final "0" in its number, indicating a transcontinental designation, the 1926 route formerly ended in Springfield, Missouri, at its intersection with the majorly famous U.S. Route 66 (US 66). In fact, US 66 was almost given the US 60 number.
The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, east of Interstate 101 (I-101) in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Los Angeles, California, but that was moved to southwest of Brenda, Arizona to an interchange with Interstate 10 (I-10) after the highway designation was removed from California in 1964. Some US 60 signs can be seen at this interchange about 5 miles (8 km) southwest of Brenda. I-10 replaced US 60 from Beaumont, California to Arizona, and California State Route 60 (CA 60) replaced US 60 from Los Angeles to Beaumont.