U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south U.S. Highway in the Eastern United States. Despite encroaching Interstate Highways, the route has remained a long-haul route, connecting the Gulf of Mexico with Lake Erie.
The highway's southern terminus is at Memphis, Florida, which is just south of St. Petersburg at an intersection with U.S. Route 41 and US 41 Business. Its northern terminus is in Erie, Pennsylvania, at an intersection with U.S. Route 20 about two miles (3 km) from the shores of Lake Erie.
The length of the highway is 1,438 miles (2,314 km), including both U.S. Route 19E and U.S. Route 19W paths through North Carolina and Tennessee.