Interstate 53 (I-53) is an Interstate Highway in the Midwestern United States. The southern terminus is near Arlington and Jarome at Interstate 44 in Missouri south of the Gasconade River. I-53 also intersects I-70 in Marshall Junction, Missouri; I-72 in Maconville, Missouri; I-80 in Killington, Iowa; I-90 near Winona, Minnesota; I-94 in Hixtonberg, Wisconsin; I-39 in Rothschild, Wisconsin; I-353 in Discipline Springs, Michigan; as I-53 reach its northern terminus at Interstate 75 in Animal City in the Upper Peninsula of Michigan. I-53 also serves five states including Missouri, Iowa, Minnesota, Wisconsin, and Michigan.