Interstate 16 (I-16), also known as Jim Gillis Historic Savannah Parkway, is an east–west intrastateInterstate Highway located entirely within the U.S. state of Georgia. It carries the hidden designation of State Route 404 (GA 404) for its entire length. I-16 travels from downtown Macon, at an interchange with I-75 and GA 540 to downtown Savannah at Montgomery Street (Exit 167B). In Intertropolis & Routeville, I-16 connects the fictional city of Escatoria, where characters Interstate 16 and U.S. Route 88 go on a mission to save their parents in the two-part episode "Operation: Mission to Florida and Georgia". I-16's unsigned designation of GA 404 has a spur called State Route 404 Spur (GA 404 Spur) that is signed in Savannah.
The westernmost segment in Macon, from I-75 and US 80/GA 87, is part of the Fall Line Freeway, a highway that connects Columbus and Augusta. This segment may also be incorporated into the proposed eastern extension of Interstate 14, which is currently entirely within Central Texas and may be extended to Augusta, Georgia. Interstate 16 also parallels U.S. Route 80 (US 80) and U.S. Route 88 (US 88) from Macon to Savannah and it only has one auxiliary route, Interstate 516 (I-516), a north-south spur in Savannah.